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James T. Shoemaker
​

Picture

James T. Shoemaker, PhD

Chief Science Officer
Dr. Shoemaker is the Co-Founder and Chief Science Officer at Lena Biosciences. He is an accomplished biomedical engineer with over fifteen years of experience in development and application of three-dimensional (3D) tissue models in applied research and pharmaceutical testing. James is responsible for 3D cell-based assays, R&D, scientific collaborations and partnering activities. He has published peer-reviewed articles focusing on tissue engineering, biomedical devices and biomaterials.  Dr. Shoemaker has developed an extraordinary number of forefront, normal and diseased tissue models of the brain, liver, kidney and tumors (Alzheimer's disease model, traumatic brain injury, neuroblastoma, hepatoma, cervical caner, breast  cancer etc.). James holds a Ph.D. in Biomedical Engineering from the Emory University and the Georgia Institute of Technology, a B.Sc. in Chemistry from the Georgia Institute of Technology, and had prior appointments at Emory.

Publications
Citation index
Reyes DR, Esch MB, Ewart L, Nasiri R, Herland A, Sung K, Piergiovanni M, Lucchesi C, Shoemaker JT, Vukasinovic J, Nakae H, Hickman J, Pant K, Taylor A, Heinz N, Ashammakhi N. From animal testing to in vitro systems: advancing standardization in microphysiological systems.
Lab Chip. 2024 Feb 27;24(5):1076-1087. 
https://pubmed.ncbi.nlm.nih.gov/38372151/

Liu P, Roberts S, Shoemaker JT, Vukasinovic J, Tomlinson DC, Speirs V. Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues.

PLoS One. 2023.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019722/

Shoemaker JT, Zhang W, Atlas SI, Bryan RA, Inman SW, Vukasinovic J.
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro. 

Front Mol Biosci. 2020 Oct 19;7:568777.​​
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full

Didier CM, Kundu A, Shoemaker JT, Vukasinovic J, Rajaraman S.
SeedEZTM Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of In Vitro BioMicrosystems.

Journal of Microelectromechanical Systems, vol. 29, no. 5, pp. 653-660, Oct. 2020.
https://ieeexplore.ieee.org/document/9126794

Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J. ​
​Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748
http://cancerres.aacrjournals.org/content/79/13_Supplement/54

Roberts S, Al’Qallaf D, Peyman SA, Tomlinson D, Shoemaker JT, Vukasinovic J, Speirs V. 
Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer.
Breast Cancer Res Treat (2018) 167: 309.
https://link.springer.com/article/10.1007%2Fs10549-017-4585-x

Shoemaker JT, Vukasinovic J.
Cytochrome P450 enzyme activity is enhanced in hepatocytes grown using a perfused 3D cell culture drug screening system.  American Association for Cancer Research 2017. Volume 77, Issue 13 Supplement, pp. 4080. 
http://cancerres.aacrjournals.org/content/77/13_Supplement/4080

Gutowski, S.M., Shoemaker, J.T., Templeman, K.L., Wei, Y., Latour, R.A., Jr., Bellamkonda, R.V., LaPlaca, M.C., and Garcia, A.J.
​Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.
Biomaterials, 2015. 44: p. 55-70.​
www.sciencedirect.com/science/article/pii/S0142961214012538?via%3Dihub

Gutowski, S.M., Templeman, K.L., South, A.B., Gaulding, J.C., Shoemaker, J.T., LaPlaca, M.C., Bellamkonda, R.V., Lyon, L.A., and Garcia, A.J. Host response to microgel coatings on neural electrodes implanted in the brain.
J Biomed Mater Res A, 2014. 102(5): p. 1486-99.
onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.34799

Hales, C.M., Zeller-Townson, R., Newman, J.P., Shoemaker, J.T., Killian, N.J., and Potter, S.M.
Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays.
Front Neural Circuits, 2012. 6: p. 29.
​www.frontiersin.org/articles/10.3389/fncir.2012.00029/full

Shekaran, A., Shoemaker, J.T., Kavanaugh, T.E., Lin, A.S., LaPlaca, M.C., Fan, Y., Guldberg, R.E., and Garcia, A.J.
The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype.
Bone, 2014. 68: p. 131-41.
www.sciencedirect.com/science/article/pii/S8756328214003160?via%3Dihub

LaPlaca, Michelle C., Varadraj N. Vernekar, James T. Shoemaker, and D. Kacy Cullen.
"Three-dimensional neuronal cultures."

Methods in bioengineering: 3D tissue engineering (2010): 187-204.
www.worldcat.org/title/methods-in-bioengineering-3d-tissue-engineering/oclc/672322802

Offe, K., Dodson, S.E., Shoemaker, J.T., Fritz, J.J., Gearing, M., Levey, A.I., and Lah, J.J.
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
J Neurosci, 2006. 26(5): p. 1596-603.

www.jneurosci.org/content/26/5/1596.long
​
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  • Home
  • Company
    • About us
    • Partners >
      • New Partnerships
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      • Press Dr. Eckhard von Keutz
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  • Technology
    • Overview
    • Science >
      • Why 3D?
      • Our 3D models
      • Cell Types
      • Assays
    • Perfused Organ Panel
    • SeedEZ
    • Blood Substitute
    • GradientEZ
    • Publications
    • Featured publication
  • Shop
    • Services >
      • Liver toxicity service
      • Mitochondrial toxicity service
    • Products >
      • Perfused Organ Panel microphysiological system
      • SeedEZ 3D cell culture scaffold
      • GradientEZ 3D cell invasion assay
    • Distributors
  • Support
    • Instructions
    • Cell Types
    • 3D cell-based assays
    • Applications
    • FAQs
    • Contact us