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James T. Shoemaker, PhDChief Science Officer
Dr. Shoemaker is an accomplished biomedical engineer with ten years of experience in development and application of three-dimensional (3D) tissue models in applied research and pharmaceutical testing. James is responsible for 3D cell-based assays, pre-clinical device R&D, scientific collaborations and partnering activities. He has published peer-reviewed articles focusing on tissue engineering, biomedical devices and biomaterials, and frequently presents at conferences and symposiums. James has developed an extraordinary number of forefront tissue models, using primary cells, secondary cells, and cell lines, spanning normal tissue models (brain, liver, kidney, bone, etc.) and diseased tissue models (neuroblastoma, cervical cancer, breast cancer, hepatoma, etc). Prior to joining Lena Biosciences, James held research positions at Emory University. Dr. Shoemaker holds a Ph.D. in Biomedical Engineering from Emory University and the Georgia Institute of Technology and a B.Sc. in Chemistry from the Georgia Institute of Technology.
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Publications
Citation index
Citation index
Shoemaker JT, Zhang W, Atlas SI, Bryan RA, Inman SW, Vukasinovic J.
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Didier CM, Kundu A, Shoemaker JT, Vukasinovic J, Rajaraman S.
SeedEZTM Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of In Vitro BioMicrosystems.
Journal of Microelectromechanical Systems, vol. 29, no. 5, pp. 653-660, Oct. 2020.
https://ieeexplore.ieee.org/document/9126794
Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J.
Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748
http://cancerres.aacrjournals.org/content/79/13_Supplement/54
Roberts S, Al’Qallaf D, Peyman SA, Tomlinson D, Shoemaker JT, Vukasinovic J, Speirs V.
Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer.
Breast Cancer Res Treat (2018) 167: 309.
https://link.springer.com/article/10.1007%2Fs10549-017-4585-x
Shoemaker JT, Vukasinovic J.
Cytochrome P450 enzyme activity is enhanced in hepatocytes grown using a perfused 3D cell culture drug screening system. American Association for Cancer Research 2017. Volume 77, Issue 13 Supplement, pp. 4080.
http://cancerres.aacrjournals.org/content/77/13_Supplement/4080
Gutowski, S.M., Shoemaker, J.T., Templeman, K.L., Wei, Y., Latour, R.A., Jr., Bellamkonda, R.V., LaPlaca, M.C., and Garcia, A.J.
Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.
Biomaterials, 2015. 44: p. 55-70.
www.sciencedirect.com/science/article/pii/S0142961214012538?via%3Dihub
Gutowski, S.M., Templeman, K.L., South, A.B., Gaulding, J.C., Shoemaker, J.T., LaPlaca, M.C., Bellamkonda, R.V., Lyon, L.A., and Garcia, A.J. Host response to microgel coatings on neural electrodes implanted in the brain.
J Biomed Mater Res A, 2014. 102(5): p. 1486-99.
onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.34799
Hales, C.M., Zeller-Townson, R., Newman, J.P., Shoemaker, J.T., Killian, N.J., and Potter, S.M.
Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays.
Front Neural Circuits, 2012. 6: p. 29.
www.frontiersin.org/articles/10.3389/fncir.2012.00029/full
Shekaran, A., Shoemaker, J.T., Kavanaugh, T.E., Lin, A.S., LaPlaca, M.C., Fan, Y., Guldberg, R.E., and Garcia, A.J.
The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype.
Bone, 2014. 68: p. 131-41.
www.sciencedirect.com/science/article/pii/S8756328214003160?via%3Dihub
LaPlaca, Michelle C., Varadraj N. Vernekar, James T. Shoemaker, and D. Kacy Cullen.
"Three-dimensional neuronal cultures."
Methods in bioengineering: 3D tissue engineering (2010): 187-204.
www.worldcat.org/title/methods-in-bioengineering-3d-tissue-engineering/oclc/672322802
Offe, K., Dodson, S.E., Shoemaker, J.T., Fritz, J.J., Gearing, M., Levey, A.I., and Lah, J.J.
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
J Neurosci, 2006. 26(5): p. 1596-603.
www.jneurosci.org/content/26/5/1596.long
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Didier CM, Kundu A, Shoemaker JT, Vukasinovic J, Rajaraman S.
SeedEZTM Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of In Vitro BioMicrosystems.
Journal of Microelectromechanical Systems, vol. 29, no. 5, pp. 653-660, Oct. 2020.
https://ieeexplore.ieee.org/document/9126794
Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J.
Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748
http://cancerres.aacrjournals.org/content/79/13_Supplement/54
Roberts S, Al’Qallaf D, Peyman SA, Tomlinson D, Shoemaker JT, Vukasinovic J, Speirs V.
Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer.
Breast Cancer Res Treat (2018) 167: 309.
https://link.springer.com/article/10.1007%2Fs10549-017-4585-x
Shoemaker JT, Vukasinovic J.
Cytochrome P450 enzyme activity is enhanced in hepatocytes grown using a perfused 3D cell culture drug screening system. American Association for Cancer Research 2017. Volume 77, Issue 13 Supplement, pp. 4080.
http://cancerres.aacrjournals.org/content/77/13_Supplement/4080
Gutowski, S.M., Shoemaker, J.T., Templeman, K.L., Wei, Y., Latour, R.A., Jr., Bellamkonda, R.V., LaPlaca, M.C., and Garcia, A.J.
Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.
Biomaterials, 2015. 44: p. 55-70.
www.sciencedirect.com/science/article/pii/S0142961214012538?via%3Dihub
Gutowski, S.M., Templeman, K.L., South, A.B., Gaulding, J.C., Shoemaker, J.T., LaPlaca, M.C., Bellamkonda, R.V., Lyon, L.A., and Garcia, A.J. Host response to microgel coatings on neural electrodes implanted in the brain.
J Biomed Mater Res A, 2014. 102(5): p. 1486-99.
onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.34799
Hales, C.M., Zeller-Townson, R., Newman, J.P., Shoemaker, J.T., Killian, N.J., and Potter, S.M.
Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays.
Front Neural Circuits, 2012. 6: p. 29.
www.frontiersin.org/articles/10.3389/fncir.2012.00029/full
Shekaran, A., Shoemaker, J.T., Kavanaugh, T.E., Lin, A.S., LaPlaca, M.C., Fan, Y., Guldberg, R.E., and Garcia, A.J.
The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype.
Bone, 2014. 68: p. 131-41.
www.sciencedirect.com/science/article/pii/S8756328214003160?via%3Dihub
LaPlaca, Michelle C., Varadraj N. Vernekar, James T. Shoemaker, and D. Kacy Cullen.
"Three-dimensional neuronal cultures."
Methods in bioengineering: 3D tissue engineering (2010): 187-204.
www.worldcat.org/title/methods-in-bioengineering-3d-tissue-engineering/oclc/672322802
Offe, K., Dodson, S.E., Shoemaker, J.T., Fritz, J.J., Gearing, M., Levey, A.I., and Lah, J.J.
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
J Neurosci, 2006. 26(5): p. 1596-603.
www.jneurosci.org/content/26/5/1596.long