Perfused Organ Panel
Our unique microphysiologial system platform, Perfused Organ Panel, accelerates the development of pharmaceutical, cosmetic, chemical, and precision medicine products. Our exploratory platform is used during the preclinical stages of product development to quickly predict the effects a certain drug or a chemical will have on the human body. The platform is comprised of PerfusionPal integral insert system, the SeedEZ scaffolds, Blood Substitute which mimics the functions of hemoglobin in cell culture perfusion, and a pump set to deliver physiological, interstitial flow rates.
In the human body, over 98% of oxygen is delivered to tissues by hemoglobin contained in red blood cells. By way of the Blood Substitute and the pump our microphysiological platform provides, for the first time, in vivo-like oxygen delivery to tissues cultured in vitro.
Elements of our microphysiological system
Perfused Organ Panel
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SeedEZ Scaffolds
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Blood Substitute
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Perfused Organ PanelPerfused Organ Panel microphysiological system is a cutting edge research tool that allows cells to grow in an environment that mimics the human body. Its exclusive design enables continuous perfusion of up to 96 different cultures at one time.
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Human-relevant
Provides accurate data that assists researchers in identifying new drug targets & biomarkers
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Advanced
Allows researchers to zero-in on the most promising treatments in drug design and development
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Efficient and humane
Improves characterization of human cells and diseases in vitro to reduce the use of animal models
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Adjustable flow rate
Users can program the flow rates to mimic those in the body in various organs and organ systems
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SeedEZSeedEZ is a cell culture scaffold that enables cells to grow in three dimensions (3D) as in living tissues. It supports all cell types and extracellular matrices (ECMs) allowing for cell-cell and cell-ECM signaling for physiologically relevant functions in vitro.
Patent No. 9,334,473. |
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Robust models
Enables researchers to make co-cultures of two, three or more different cell types
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Assay multiplexing
Multiple functions can be assessed with multiplexed mix-and-measure assays
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Portable cultures
Routine transfer of cultures from a plate to a dish for high-resolution imaging
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Reproducible results
Defined cell distribution in x, y, and z, yields precise results across experiments
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Blood SubstituteOur proprietary synthetic hemoglobin, Blood Substitute, provides efficient delivery of atmospheric gases to the cells growing in our platform. It enables superior oxygen delivery and pH maintenance by mimicking the functions of hemoglobin which results in increased cell viability and function in vitro.
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Superior oxygenation
Ensures that cells throughout the system receive oxygen and other gases uniformly
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pH stability
Improves delivery of carbon dioxide for stable and balanced pH environment
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Improved function
Enhances cell respiratory and drug metabolism, and organ-specific functions
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Extended studies
Increases cell longevity, eliminating time restriction on research
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