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Wanrui Zhang, PhDResearch Scientist
Dr. Zhang has over a decade of research experience in diverse directions, working in both industrial and academic settings. Her research has been focused on drug and chemical metabolism in primary human hepatocytes, the intrinsic mechanisms of mitochondrial superoxide production and its regulation by external stimuli in cardiomyocytes, and the identification and characterization of hepatitis C virus-specific B cells. Dr. Zhang has an impressive publication record resulting from her research. She holds B.Sc. in Biology and Ph.D. in Mitochondrial Biology from Peking University, Beijing, China. Prior to joining Lena Biosciences, Dr. Zhang worked at the Yerkes National Primate Research Center at Emory University.
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Shoemaker JT, Zhang W, Atlas SI, Bryan RA, Inman SW, Vukasinovic J.
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH, Grakoui A. Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells.
J Immunol. 2016 Dec 15;197(12):4848-4858.
https://www.jimmunol.org/content/197/12/4848.long
Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Armstrong C, Zheng M, Cheng H. Kissing and nanotunneling mediate intermitochondrial communication in the heart.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2846-51.
https://www.pnas.org/content/110/8/2846.long
Li K, Zhang W, Fang H, Xie W, Liu J, Zheng M, Wang X, Wang W, Tan W, Cheng H. Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes.
Biophys J. 2012 Mar 7;102(5):1011-21.
https://www.cell.com/biophysj/fulltext/S0006-3495(12)00159-2
Wang X, Jian C, Zhang X, Huang Z, Xu J, Hou T, Shang W, Ding Y, Zhang W, Ouyang M, Wang Y, Yang Z, Zheng M, Cheng H. Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart.
J Mol Cell Cardiol. 2012 May;52(5):940-8.
https://www.jmcc-online.com/article/S0022-2828(12)00090-9/fulltext
Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.
Cell Res. 2011 Sep;21(9):1295-304.
https://www.nature.com/articles/cr201181
Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria.
Cell. 2008 Jul 25;134(2):279-90.
https://www.cell.com/cell/fulltext/S0092-8674(08)00769-1
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen KH, Xiao RP. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.
J Biol Chem. 2007 Aug 10;282(32):23354-61.
https://www.jbc.org/article/S0021-9258(20)54548-1/fulltext
Yan Y, Wei CL, Zhang WR, Cheng HP, Liu J. Cross-talk between calcium and reactive oxygen species signaling.
Acta Pharmacol Sin. 2006 Jul;27(7):821-6.
https://www.nature.com/articles/aps2006109
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Boisvert M, Zhang W, Elrod EJ, Bernard NF, Villeneuve JP, Bruneau J, Marcotrigiano J, Shoukry NH, Grakoui A. Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells.
J Immunol. 2016 Dec 15;197(12):4848-4858.
https://www.jimmunol.org/content/197/12/4848.long
Huang X, Sun L, Ji S, Zhao T, Zhang W, Xu J, Zhang J, Wang Y, Wang X, Franzini-Armstrong C, Zheng M, Cheng H. Kissing and nanotunneling mediate intermitochondrial communication in the heart.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2846-51.
https://www.pnas.org/content/110/8/2846.long
Li K, Zhang W, Fang H, Xie W, Liu J, Zheng M, Wang X, Wang W, Tan W, Cheng H. Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes.
Biophys J. 2012 Mar 7;102(5):1011-21.
https://www.cell.com/biophysj/fulltext/S0006-3495(12)00159-2
Wang X, Jian C, Zhang X, Huang Z, Xu J, Hou T, Shang W, Ding Y, Zhang W, Ouyang M, Wang Y, Yang Z, Zheng M, Cheng H. Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart.
J Mol Cell Cardiol. 2012 May;52(5):940-8.
https://www.jmcc-online.com/article/S0022-2828(12)00090-9/fulltext
Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.
Cell Res. 2011 Sep;21(9):1295-304.
https://www.nature.com/articles/cr201181
Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide flashes in single mitochondria.
Cell. 2008 Jul 25;134(2):279-90.
https://www.cell.com/cell/fulltext/S0092-8674(08)00769-1
Shen T, Zheng M, Cao C, Chen C, Tang J, Zhang W, Cheng H, Chen KH, Xiao RP. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.
J Biol Chem. 2007 Aug 10;282(32):23354-61.
https://www.jbc.org/article/S0021-9258(20)54548-1/fulltext
Yan Y, Wei CL, Zhang WR, Cheng HP, Liu J. Cross-talk between calcium and reactive oxygen species signaling.
Acta Pharmacol Sin. 2006 Jul;27(7):821-6.
https://www.nature.com/articles/aps2006109