Patents:
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Jelena Vukasinovic, MScChief Executive Officer
Ms. Vukasinovic is the Chief Executive Officer and President at Lena Biosciences. She is a proven inventor and a successful entrepreneur. Jelena has a solid track record of bringing innovative products to market backed by twenty years of experience in medical devices, biotechnology, and life sciences. She secured financing for corporate growth, developed and protected intellectual property, and assembled an outstanding team of experienced engineers, scientists, partners, and collaborators to streamline the company's operations. Her technology developments have been funded by the small business grant awards from the National Institutes of Health, the National Science Foundation, and the Georgia Research Alliance Venture Lab. Prior to forming Lena Biosciences, Jelena served as research faculty at Georgia Tech for over ten years. Jelena holds three patents and a M.S. in Mechanical Engineering from the Georgia Institute of Technology.
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Shoemaker JT, Zhang W, Atlas SI, Bryan RA, Inman SW, Vukasinovic J.
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Didier CM, Kundu A, Shoemaker JT, Vukasinovic J, Rajaraman S.
SeedEZTM Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of In Vitro BioMicrosystems.
Journal of Microelectromechanical Systems, vol. 29, no. 5, pp. 653-660, Oct. 2020.
https://ieeexplore.ieee.org/document/9126794
Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J.
Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748
http://cancerres.aacrjournals.org/content/79/13_Supplement/54
Roberts S, Al’Qallaf D, Peyman SA, Tomlinson D, Shoemaker JT, Vukasinovic J, Speirs V.
Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer.
Breast Cancer Res Treat (2018) 167: 309.
https://link.springer.com/article/10.1007%2Fs10549-017-4585-x
Shoemaker JT, Vukasinovic J.
Cytochrome P450 enzyme activity is enhanced in hepatocytes grown using a perfused 3D cell culture drug screening system. American Association for Cancer Research 2017. Volume 77, Issue 13 Supplement, pp. 4080.
http://cancerres.aacrjournals.org/content/77/13_Supplement/4080
Killian NJ, Vernekar VN, Potter SM, Vukasinovic J.
A Device for Long-Term Perfusion, Imaging, and Electrical Interfacing of Brain Tissue In vitro.
Front Neurosci. 2016 Mar 31;10:135.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815559/
Cullen DK, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC.
Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (Part 1).
Crit Rev Biomed Eng. 2011;39(3):201-40.
https://doi.org/10.1615/critrevbiomedeng.v39.i3.30
Murphy DW, Dasi LP, Vukasinovic J, Glezer A, Yoganathan AP. Reduction of procoagulant potential of b-datum leakage jet flow in bileaflet mechanical heart valves via application of vortex generator arrays.
J Biomech Eng. 2010 Jul;132(7):071011.
https://doi.org/10.1115/1.4001260
Rambani K, Vukasinovic J, Glezer A, Potter SM.
Culturing thick brain slices: an interstitial 3D microperfusion system for enhanced viability.
J Neurosci Methods. 2009 Jun 15;180(2):243-54.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742628/
Vukasinovic J, Cullen DK, LaPlaca MC, Glezer A.
A microperfused incubator for tissue mimetic 3D cultures.
Biomed Microdevices. 2009 Dec;11(6):1155-65.
https://link.springer.com/article/10.1007%2Fs10544-009-9332-6
Choi Y, Vukasinovic J, Glezer A, Allen MG.
MEMS-based fabrication and microfluidic analysis of three-dimensional perfusion systems.
Biomed Microdevices. 2008 Jun;10(3):437-46.
https://link.springer.com/article/10.1007%2Fs10544-007-9153-4
Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB.
Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks.
Lab Chip. 2007 Apr;7(4):475-82.
https://doi.org/10.1039/b700795g
Cullen DK, Vukasinovic J, Glezer A, Laplaca MC.
Microfluidic engineered high cell density three-dimensional neural cultures.
J Neural Eng. 2007 Jun;4(2):159-72.
https://iopscience.iop.org/article/10.1088/1741-2560/4/2/015
Rajaraman S, Choi SO, Shafer RH, Ross JD, Vukasinovic J, Choi Y, DeWeerth SP, Glezer A, Allen MG.
Microfabrication technologies for a coupled three-dimensional microelectrode, microfluidic array.
Journal of Micromechanics and Microengineering. 2007. 17(1):163.
https://iopscience.iop.org/article/10.1088/0960-1317/17/1/021
Rowe L, Choi Y, Ross J, Lee K, Fogleman N, Brewer GJ, Vukasinovic J, Glezer A, DeWeerth SP, Frazier AB.
A Fully Functional, Packaged Active Microscaffold System with Fluid Perfusion and Electrical Stimulation/Recording Functionalities for 3-D Neuronal Culture Studies," TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference, Lyon, 2007, pp. 1389-1392.
https://ieeexplore.ieee.org/document/4300402
Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC.
High cell density three-dimensional neural co-cultures require continuous medium perfusion for survival.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:636-9.
https://doi.org/10.1109/IEMBS.2006.260639
Vukasinovic J, Glezer A.
Spot-Cooling by Confined, Impinging Synthetic Jet.
Proceedings of the ASME 2003 Heat Transfer Summer Conference. Heat Transfer: Volume 3. Las Vegas, Nevada, USA. July 21–23, 2003. pp. 469-476. ASME.
https://doi.org/10.1115/HT2003-47245
A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro.
Front Mol Biosci. 2020 Oct 19;7:568777.
https://www.frontiersin.org/articles/10.3389/fmolb.2020.568777/full
Didier CM, Kundu A, Shoemaker JT, Vukasinovic J, Rajaraman S.
SeedEZTM Interdigitated Electrodes and Multifunctional Layered Biosensor Composites (MLBCs): A Paradigm Shift in the Development of In Vitro BioMicrosystems.
Journal of Microelectromechanical Systems, vol. 29, no. 5, pp. 653-660, Oct. 2020.
https://ieeexplore.ieee.org/document/9126794
Shoemaker JT, Richardson KR, Arnst J, Marcus AI and Vukasinovic J.
Characterization of patient-derived organoids cultured on a gas-rich, liquid-liquid interface
American Association for Cancer Research 2019. Proceedings: Abstracts 1-2748
http://cancerres.aacrjournals.org/content/79/13_Supplement/54
Roberts S, Al’Qallaf D, Peyman SA, Tomlinson D, Shoemaker JT, Vukasinovic J, Speirs V.
Progress towards the development of a fully humanised 3D cell culture model of HER2+ breast cancer.
Breast Cancer Res Treat (2018) 167: 309.
https://link.springer.com/article/10.1007%2Fs10549-017-4585-x
Shoemaker JT, Vukasinovic J.
Cytochrome P450 enzyme activity is enhanced in hepatocytes grown using a perfused 3D cell culture drug screening system. American Association for Cancer Research 2017. Volume 77, Issue 13 Supplement, pp. 4080.
http://cancerres.aacrjournals.org/content/77/13_Supplement/4080
Killian NJ, Vernekar VN, Potter SM, Vukasinovic J.
A Device for Long-Term Perfusion, Imaging, and Electrical Interfacing of Brain Tissue In vitro.
Front Neurosci. 2016 Mar 31;10:135.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815559/
Cullen DK, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC.
Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (Part 1).
Crit Rev Biomed Eng. 2011;39(3):201-40.
https://doi.org/10.1615/critrevbiomedeng.v39.i3.30
Murphy DW, Dasi LP, Vukasinovic J, Glezer A, Yoganathan AP. Reduction of procoagulant potential of b-datum leakage jet flow in bileaflet mechanical heart valves via application of vortex generator arrays.
J Biomech Eng. 2010 Jul;132(7):071011.
https://doi.org/10.1115/1.4001260
Rambani K, Vukasinovic J, Glezer A, Potter SM.
Culturing thick brain slices: an interstitial 3D microperfusion system for enhanced viability.
J Neurosci Methods. 2009 Jun 15;180(2):243-54.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742628/
Vukasinovic J, Cullen DK, LaPlaca MC, Glezer A.
A microperfused incubator for tissue mimetic 3D cultures.
Biomed Microdevices. 2009 Dec;11(6):1155-65.
https://link.springer.com/article/10.1007%2Fs10544-009-9332-6
Choi Y, Vukasinovic J, Glezer A, Allen MG.
MEMS-based fabrication and microfluidic analysis of three-dimensional perfusion systems.
Biomed Microdevices. 2008 Jun;10(3):437-46.
https://link.springer.com/article/10.1007%2Fs10544-007-9153-4
Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB.
Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks.
Lab Chip. 2007 Apr;7(4):475-82.
https://doi.org/10.1039/b700795g
Cullen DK, Vukasinovic J, Glezer A, Laplaca MC.
Microfluidic engineered high cell density three-dimensional neural cultures.
J Neural Eng. 2007 Jun;4(2):159-72.
https://iopscience.iop.org/article/10.1088/1741-2560/4/2/015
Rajaraman S, Choi SO, Shafer RH, Ross JD, Vukasinovic J, Choi Y, DeWeerth SP, Glezer A, Allen MG.
Microfabrication technologies for a coupled three-dimensional microelectrode, microfluidic array.
Journal of Micromechanics and Microengineering. 2007. 17(1):163.
https://iopscience.iop.org/article/10.1088/0960-1317/17/1/021
Rowe L, Choi Y, Ross J, Lee K, Fogleman N, Brewer GJ, Vukasinovic J, Glezer A, DeWeerth SP, Frazier AB.
A Fully Functional, Packaged Active Microscaffold System with Fluid Perfusion and Electrical Stimulation/Recording Functionalities for 3-D Neuronal Culture Studies," TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference, Lyon, 2007, pp. 1389-1392.
https://ieeexplore.ieee.org/document/4300402
Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC.
High cell density three-dimensional neural co-cultures require continuous medium perfusion for survival.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:636-9.
https://doi.org/10.1109/IEMBS.2006.260639
Vukasinovic J, Glezer A.
Spot-Cooling by Confined, Impinging Synthetic Jet.
Proceedings of the ASME 2003 Heat Transfer Summer Conference. Heat Transfer: Volume 3. Las Vegas, Nevada, USA. July 21–23, 2003. pp. 469-476. ASME.
https://doi.org/10.1115/HT2003-47245