​ENGINEERED LIVER MODEL ​FOR PREDICTIVE TOXICOLOGY

Our proprietary assays scan through cellular vulnerabilities to find the origin of toxicity in a drug metabolism-competent 3D, MPS human liver model

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Additional drug-induced liver injury data
​predominantly with anti-cancer drugs

The table lists the lowest IC50 using a few assays at the most, after a 24-hour drug treatment

STRUCTURALLY SIMILAR DRUG PAIR
Adjunctive therapies for idiopathic Parkinson’s disease
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Tolcapone
BOXED WARNING
Risk of potentially fatal, acute fulminant liver failure

• Has a potential reactive metabolite
• Almost completely metabolized prior to excretion
• Excretion: urine (60%) and feces (40%)

Entacapone
Postmarketing Reports
Hepatitis with mainly cholestatic features

• Almost completely metabolized prior to excretion
• Excretion: feces (90%) and urine (10%)

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​​​​​WATCH HOW OUR ASSAYS DE-RISK COMPOUNDS EARLY

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