​ENGINEERED LIVER MODEL ​FOR PREDICTIVE TOXICOLOGY

Our proprietary assays scan through cellular vulnerabilities to find the origin of toxicity in a drug metabolism-competent 3D human liver model

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ONE DRUG TREATMENT, 24-HOUR READOUTS​​

​The listed IC50 is for the "trigger", the first function which fails.​

ONE DRUG TREATMENT, 24-HOUR READOUTS​​

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​The below table lists the lowest IC50 obtained from a maximum of few assays, following a 24-hour drug treatment.

DILI DATA WITH ANTI-CANCER DRUGS

STRUCTURALLY SIMILAR DRUG PAIR
Adjunctive therapies for idiopathic Parkinson’s disease
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Tolcapone
BOXED WARNING
Risk of potentially fatal, acute fulminant liver failure

• Has a potential reactive metabolite
• Almost completely metabolized prior to excretion
• Excretion: urine (60%) and feces (40%)

Entacapone
Postmarketing Reports
Hepatitis with mainly cholestatic features

• Almost completely metabolized prior to excretion
• Excretion: feces (90%) and urine (10%)

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