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​Services​​

Technology-enabled actionable insights for drug discovery

​​
​​Watch how Lena Biosciences' services de-risk drugs early
​​In this webinar, Dr. James T. Shoemaker, Chief Science Officer at Lena Biosciences takes a deep dive into drug-induced liver injury (DILI), the biggest cause of safety-related drug withdrawals. He shares how a combination of innovative technologies detects DILI signal and isolates the trigger that leads to toxicity, thus providing actionable intelligence for early drug de-risking.  ​ 

Highlights: 
  • High-sensitivity assays probe cellular vulnerabilities to find the toxicity trigger
  • The relevance of that signal for early drug de-risking 
  • Dose-dependent changes in the mechanism of toxicity 
  • How to interpret early warning signs
  • How to exclude patient groups at risk

​Services offered with SeedEZ and Perfused Organ Panel products
Our services are also available at ScienceExchange.com and Scientist.com
HEPATOTOXICITY AND DRUG-INDUCED LIVER INJURY
We offer standard cytotoxicity service and proprietary screens to isolate the toxicity trigger, dose-dependent changes in the mechanism of toxicity and active mechanisms for a given dose. 
Lena Biosciences' DILI brochure digital
File Size: 727 kb
File Type: pdf
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Lena Biosciences' DILI brochure print
File Size: 935 kb
File Type: pdf
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MITOCHONDRIAL TOXICITY
The service is offered with a xenobiotic metabolism-competent model to assess the effect of  the parent compound and its metabolites. Proprietary assays probe specific mitochondrial functions.
Mitochondrial toxicity predictions for 25 drugs
File Size: 247 kb
File Type: pdf
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3D CELL-BASED ASSAYS
The assays can be run with primary cells, cell lines and iPSC-derived cells. Our panels of proprietary assays can be deployed to answer specific questions.
  • Organ models: liver, brain and tumors.  
  • Normal tissue models: 3D cell culture and co-culture models. 
  • Tumors: we can test small molecules and biologics.
T cells can be included in the model.​​
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ORGAN-ON-A-CHIP AND MICROPHYSIOLOGICAL SYSTEM (MPS) SERVICE
The studies are run in Perfused Organ Panel. For assays, see 3D cell-based assays.
3D models offered: liver, brain, and tumors. We can include T cells.
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3D CELL CULTURE MODELS​
We generate advanced 3D tissue models using co-cultures of primary cells or cell lines based on your specifications, or using cells provided by you. The models are cultured in 3D in our SeedEZ scaffold. ​For assays, see 3D cell-based assays.
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  • Home
  • Company
    • About us
    • Partners >
      • New Partnerships
    • Careers
    • News >
      • Press Dr. Eckhard von Keutz
    • Events
  • Technology
    • Overview
    • Science >
      • Why 3D?
      • Our 3D models
      • Cell Types
      • Assays
    • Perfused Organ Panel
    • SeedEZ
    • Blood Substitute
    • GradientEZ
    • Publications
    • Featured publication
  • Shop
    • Services >
      • Liver toxicity service
      • Mitochondrial toxicity service
    • Products >
      • Perfused Organ Panel microphysiological system
      • SeedEZ 3D cell culture scaffold
      • GradientEZ 3D cell invasion assay
    • Distributors
  • Support
    • Instructions
    • Cell Types
    • 3D cell-based assays
    • Applications
    • FAQs
    • Contact us