ASSESS THE EFFECT OF THE DRUG AND ITS METABOLITES​
ON MITOCHONDRIAL FUNCTION
​
Oxidative metabolism-competent and drug metabolism-competent 3D, MPS model​

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KINASE INHIBITORS
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​​Sorafenib: IC50/Cmax = 0.2
Main CYP: 3A4

Ceritinib: IC50/Cmax = 1
Main CYP: 3A

Crizotinib: IC50/Cmax = 8
Main CYP: 3A4/5
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Ruxolitinib: IC50/Cmax = 19
Main CYP: 3A4

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CHEMICALS
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​​Triclocarban IC50: 0.6 uM
IC50 dose: 0.7 picogram/cell

Lasalocid IC50: 1 uM
IC50 dose: 3.2 picogram/cell

Picoxystrobin IC50: 2 uM
IC50 dose: 3.1 picogram/cell
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Pinacyanol IC50: 5 uM
IC50 dose: 9.1 picogram/cell

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​REFERENCE STANDARDS
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Standard	IC50 [nM]
Rotenone (complex I)	20
Antimycin A (complex III)	2
Oligomycin A (complex V)	13
FCCP (uncoupler)	119
CCCP (uncoupler)	201

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